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ZJH-16

CAT: 0804-HY-148641Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148641Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM) . ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers[1].
CAS Number
2877017-58-6
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2
Molecular Formula
C18H14N6O
Molecular Weight
330.34
References & Citations
[1]Dong G, et al. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED-H3K27me3 Inhibitors for the Treatment of Lymphoma. J Med Chem. 2023 Jan 12;66 (1) :1063-1081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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