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Derenofylline

CAT: 0804-HY-14858-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14858-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
CAS Number
251945-92-3
Product Name Alternative
SLV 320
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/derenofylline.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1CC[C@H](NC2=C3C(NC=C3)=NC(C4=CC=CC=C4)=N2)CC1
Molecular Formula
C18H20N4O
Molecular Weight
308.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151 (7) :1025-32.|[2]Marta Mateus, et al. Understanding the Role of Adenosine Receptors in the Myofibroblast Transformation in Peyronie's Disease. J Sex Med. 2018 Jul;15 (7) :947-957.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A3 receptor (A3R)

Alternative Products

CatalogName
T8312-01Derenofylline
C07087-5mgDerenofylline (SLV320)
A21990-25Derenofylline 25mg
A21990-50Derenofylline 50mg
A21990-200Derenofylline 200mg
A21990-100Derenofylline 100mg
A21990-10Derenofylline 10mg
A21990-5Derenofylline 5mg
A21990-10mM-DDerenofylline 10mM * 1mL in DMSO

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