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Pyronaridine-d4 (tetraphosphate)

CAT: 0804-HY-14749ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14749ASSize:1 mg
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Description
Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].
CAS Number
1186026-25-4
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
97.00
Solubility
H2O : 25 mg/mL (ultrasonic; warming)
Smiles
O=P(O)(O)O.ClC1=CC2=C(C=C1)C(NC3=CC(C([2H])([2H])N4CCCC4)=C(C(C([2H])([2H])N5CCCC5)=C3)O)=C6C(C=CC(OC)=N6)=N2.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
Molecular Formula
C29H40D4ClN5O18P4
Molecular Weight
914.06
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105 (3) :222-8.|[3]Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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