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Feniralstat (hydrochloride)

CAT: 0804-HY-145568ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145568ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Feniralstat (compound 30) hydrochloride, a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal) . Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM) [1].
CAS Number
2340299-00-3
UNSPSC
12352005
Target
Kallikrein
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=C1C=CC(F)=CN1CC2=CC=C(CN3N=C(COC)C(C(NCC4=NC=CC(OC)=C4F)=O)=C3)C=C2.Cl
Molecular Formula
C26H26ClF2N5O4
Molecular Weight
545.97
References & Citations
[1]Rebecca Louise DAVIE, et al. Pyrazole derivatives as plasma kallikrein inhibitors. WO2017207983A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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