SEP-4199

• Description:

  SEP-4199 is a nonracemic 85:15 ratio of Aramisulpride (HY-109167) and Esamisulpride (HY-126068) . SEP-4199 exhibits significant differences in relative potency at two different receptors (5-HT7R and D2R) compared to the racemate. SEP-4199 exhibits antidepressant effects[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  CCN1[C@@H](CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1.CCN3[C@H](CNC(C4=CC(S(=O)(CC)=O)=C(N)C=C4OC)=O)CCC3

• Molecular Formula:

  C17H27N3O4S

• Molecular Weight:

  369.48

• References & Citations:

  [1]Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110 (3) :808-815.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT7 Receptor; D2 Receptor

• CAS Number:

  [2974362-88-2]