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Tesofensine (Standard)

CAT: 0804-HY-14472R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14472R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tesofensine (Standard) is the analytical standard of Tesofensine. This product is intended for research and analytical applications. Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE; IC50=1.7 nM), and serotonin (5-HT; IC50=11 nM), and with potentials as an anti-obesity agent[1]. Tesofensine is a CNS acting anti-obesity agent[2].
CAS Number
195875-84-4
UNSPSC
12352100
Target
Dopamine Transporter; Reference Standards; Serotonin Transporter
Related Pathways
Neuronal Signaling; Others
Field of Research
Metabolic Disease
Smiles
CN1[C@@]2([H])[C@H](COCC)[C@@H](C3=CC=C(Cl)C(Cl)=C3)C[C@]1([H])CC2
Molecular Formula
C17H23Cl2NO
Molecular Weight
328.28
References & Citations
[1]Lieuwe Appel, et al. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. Eur Neuropsychopharmacol. 2014 Feb;24 (2) :251-61.|[2]Ann A Coulter, et al. Centrally Acting Agents for Obesity: Past, Present, and Future. Drugs. 2018 Jul;78 (11) :1113-1132.|[3]Anne Marie D Axel, et al. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.Neuropsychopharmacology. 2010 Jun;35 (7) :1464-76.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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