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Casopitant

CAT: 0804-HY-14405Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14405Size:1 Each
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Description
Casopitant (GW679769) is a potent, selective, brain-penetrant and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant antagonizes the emetic effects of Substance P. Casopitant is also a substrate and weak to moderate inhibitor of CYP3A4. Casopitant is indicated for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).
CAS Number
414910-27-3
Product Name Alternative
GW679769
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Cytochrome P450; Neurokinin Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N1[C@@H](C2=CC=C(F)C=C2C)C[C@@H](N3CCN(C(C)=O)CC3)CC1)N([C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)C
Molecular Formula
C30H35F7N4O2
Molecular Weight
616.61
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Ruhlmann C, et al. Casopitant: a novel NK (1) -receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag. 2009 Apr;5 (2) :375-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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