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Selegiline-d5

CAT: 0804-HY-14198SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14198SSize:1 Each
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Description
Selegiline-d5 (Deprenyl-d5) is deuterium labeled Selegiline. Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM) . Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3].
CAS Number
1217976-51-6
Product Name Alternative
Deprenyl-d5; (-) -Selegiline-d5; (-) -Deprenyl-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Monoamine Oxidase
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
C#CCN(C)[C@H](C)CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H]
Molecular Formula
C13H12D5N
Molecular Weight
192.31
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana) . Molecules. 2019 Feb 23;24 (4) :810.|[3]Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-) -deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47 (6 Suppl 3) :S171-83.|[4]MohanKumar PS, et, al. Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro. Brain Res Bull. 2001 Apr;54 (6) :675-80.|[5]Ho MC, et, al. Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice. Psychopharmacology (Berl) . 2009 Jul;205 (1) :141-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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