Methyltetrazine-PEG8-PFP ester

• Description:

  Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG8-PFP ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PROTAC Linkers

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  98.06

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (OC1=C (F) C (F) =C (F) C (F) =C1F) CCOCCOCCOCCOCCOCCOCCOCCOCCOC2=CC=C (C3=NN=C (C) N=N3) C=C2

• Molecular Formula:

  C34H43F5N4O11

• Molecular Weight:

  778.72

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Alkyl/ether Linkers; PEG Linkers

• CAS Number:

  2353409-49-9