Stattic (Standard)

CAT: 0804-HY-13818R-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-13818R-01Size:5 mg

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Description

Stattic (Standard) is the analytical standard of Stattic. This product is intended for research and analytical applications. Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) [1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].

CAS Number

19983-44-9

UNSPSC

12352100

Target

Apoptosis; Reference Standards; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]

Molecular Formula

C8H5NO4S

Molecular Weight

211.19

References & Citations

[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.|[2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13 (11) :1123-4.|[3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33 (2) :214-223.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Chemical Information

Stattic

Stattic is a member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma. It has a role as a radiosensitizing agent, an antineoplastic agent and a STAT3 inhibitor. It is a C-nitro compound, a sulfone and a member of 1-benzothiophenes.

CAS Number	19983-44-9
PubChem CID	2779853
IUPAC Name	6-nitro-1-benzothiophene 1,1-dioxide
Molecular Formula	C8H5NO4S
Molecular Weight	211.20
XLogP	0.7
Topological Polar Surface Area	88.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Heavy Atom Count	14
Formal Charge	0
Complexity	375

SMILES

C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

InChI

InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChIKey

ZRRGOUHITGRLBA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 19983-44-9

CID: 2779853

Formula: C8H5NO4S

MW: 211.20

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	211.20
XLogP3	0.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	210.99392881
Monoisotopic Mass	210.99392881
Topological Polar Surface Area	88.3 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	375
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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