Products for Research Use Only
RegisterLogin

Stattic

CAT: 0804-HY-13818-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13818-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) [1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].
CAS Number
19983-44-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Stattic.html
Purity
99.58
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]
Molecular Formula
C8H5NO4S
Molecular Weight
211.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.|[2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13 (11) :1123-4.|[3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33 (2) :214-223.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

Related Products

CatalogName
HY-P75731EGFL7/VE-Statin, Mouse (sf9, His)
HY-P75730-01EGFL7/VE-Statin, Human (sf9, His)

Alternative Products

CatalogName
A2224-25Stattic

Popular Products