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ALC-0315 (GMP Like)

CAT: 0804-HY-138170GL-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138170GL-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALC-0315 (GMP Like) is ALC-0315 produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine[1].
CAS Number
2036272-55-4
UNSPSC
12352211
Hazard Statement
H315-H319
Target
Liposome; SARS-CoV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O
Molecular Formula
C48H95NO5
Molecular Weight
766.27
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29 (3) :898-900.|[2]Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm. 2022;19 (7) :2175-2182.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Chemical Information

Alc-0315
CAS Number2036272-55-4
PubChem CID122666778
IUPAC Name6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate
Molecular FormulaC48H95NO5
Molecular Weight766.3
XLogP17.3
Topological Polar Surface Area76.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count46
Heavy Atom Count54
Formal Charge0
Complexity718
SMILES
CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)CCCCO
InChI
InChI=1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3
InChIKey
QGWBEETXHOVFQS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Alc-0315
CAS: 2036272-55-4
CID: 122666778
Formula: C48H95NO5
MW: 766.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight766.3
XLogP317.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count46
Exact Mass765.72102513
Monoisotopic Mass765.72102513
Topological Polar Surface Area76.1 Ų
Heavy Atom Count54
Formal Charge0
Complexity718
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
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HY-153389ALC-0315 analogue-3
HY-153379ALC-0315 analogue-1
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