SC-514 (Standard)

• Description :

  SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

• UNSPSC :

  12352100

• Target :

  IKK; Reference Standards

• Related Pathways :

  NF-κB; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C(N)C=C(C2=CSC=C2)S1)N

• Molecular Formula :

  C9H8N2OS2

• Molecular Weight :

  224.30

• References & Citations :

  [1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [354812-17-2]