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NS8593

CAT: 0804-HY-137952Size: 1 EachDry Ice: NoHazardous: No
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Description
NS8593 is an SK channel (small conductance Ca2+-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3) . NS8593 inhibits all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+) . NS8593 does not affect the Ca2+-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively) . NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC50 = 1.6 mM) . NS8593 can be used for the study of central nervous system (CNS) related diseases[1][2].
CAS Number
875755-39-8
UNSPSC
12352005
Target
Potassium Channel; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C1(N[C@@H]2CCCC3=C2C=CC=C3)=NC4=CC=CC=C4N1
Molecular Formula
C17H17N3
Molecular Weight
263.34
References & Citations
2+
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

NS-8593

NS-8593 is a member of the class of tetralins that is tetraline substituted by a 1H-benzimidazol-2-ylamino group at position 1 (the 1R-stereoisomer). It has a role as a TRP channel blocker. It is a member of benzimidazoles, a member of tetralins and a secondary amino compound.

CAS Number875755-39-8
PubChem CID11587013
IUPAC NameN-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine
Molecular FormulaC17H17N3
Molecular Weight263.34
XLogP4.1
Topological Polar Surface Area40.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity332
SMILES
C1C[C@H](C2=CC=CC=C2C1)NC3=NC4=CC=CC=C4N3
InChI
InChI=1S/C17H17N3/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20)/t14-/m1/s1
InChIKey
XZIZUQSOFMLIIR-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of NS-8593
CAS: 875755-39-8
CID: 11587013
Formula: C17H17N3
MW: 263.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight263.34
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass263.142247555
Monoisotopic Mass263.142247555
Topological Polar Surface Area40.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity332
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
sc-253203NS8593 hydrochloride
532372NS8593 HCl
217603NS8593 ((R) -N- (Benzimidazol-2-yl) -1,2,3,4-tetrahydro-1-naphthylamine)

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