IsoGTP (sodium)

• Description :

  IsoGTP (Isoguanosine-5'-O-triphosphate) sodium is an isomer of guanosine 5'-triphosphate and a phosphorylated form of Crotonoside (HY-N0071) . isoGTP sodium inhibits transcription and induces T to C mutations in a reverse transcriptase assay. isoGTP sodium is promising for research of substrate specificity of phosphofructokinase and mutT homolog 1 (MTH1) [1][2].

• Product Name Alternative :

  Isoguanosine-5'-O-triphosphate (sodium)

• UNSPSC :

  12352005

• Target :

  Nucleoside Antimetabolite/Analog

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  O=P(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)NC(N=C32)=O)O1

• Molecular Formula :

  C10H12N5Na4O14P3

• Molecular Weight :

  611.11

• References & Citations :

  [1]Kamiya H, et al. Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription. Nucleic Acids Symp Ser (Oxf) . 2006; (50) :99-100.|[2]Fujikawa K, et al. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 2001 Jan 15;29 (2) :449-54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported