IsoGTP (sodium)

• Description:

  IsoGTP (Isoguanosine-5'-O-triphosphate) sodium is an isomer of guanosine 5'-triphosphate and a phosphorylated form of Crotonoside (HY-N0071) . isoGTP sodium inhibits transcription and induces T to C mutations in a reverse transcriptase assay. isoGTP sodium is promising for research of substrate specificity of phosphofructokinase and mutT homolog 1 (MTH1) [1][2].

• Product Name Alternative:

  Isoguanosine-5'-O-triphosphate (sodium)

• UNSPSC:

  12352005

• Target:

  Nucleoside Antimetabolite/Analog

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=P (OP (OP (O[Na]) (O[Na]) =O) (O[Na]) =O) (O[Na]) OC[C@@H]1[C@@H] (O) [C@@H] (O) [C@H] (N2C=NC3=C (N) NC (N=C32) =O) O1

• Molecular Formula:

  C10H12N5Na4O14P3

• Molecular Weight:

  611.11

• References & Citations:

  [1]Kamiya H, et al. Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription. Nucleic Acids Symp Ser (Oxf) . 2006; (50) :99-100.|[2]Fujikawa K, et al. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 2001 Jan 15;29 (2) :449-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported