Dl-Tetrandrine

CAT: 0804-HY-13764ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13764ASize:1 Each
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Description
Dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca2+ influx with an IC50 value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal[1].
CAS Number
[23495-89-8]
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Smiles
COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4
Molecular Formula
C38H42N2O6
Molecular Weight
622.75
References & Citations
[1]Yupraphat T, et al. ALKALOIDE AUS DER THAILÄNDISCHEN MENISPERMACEEN–DROGE KRUNG KHA MAO[J]. Planta Medica, 1974, 25 (04) : 315-324.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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