Dl-Tetrandrine

• Description :

  Dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca2+ influx with an IC50 value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal[1].

• UNSPSC :

  12352005

• Target :

  Calcium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Smiles :

  COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4

• Molecular Formula :

  C38H42N2O6

• Molecular Weight :

  622.75

• References & Citations :

  [1]Yupraphat T, et al. ALKALOIDE AUS DER THAILÄNDISCHEN MENISPERMACEEN–DROGE KRUNG KHA MAO[J]. Planta Medica, 1974, 25 (04) : 315-324.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [23495-89-8]