Tetrandrine

• Description :

  Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

• Product Name Alternative :

  NSC-77037; d-Tetrandrine

• UNSPSC :

  12352005

• Hazard Statement :

  H300

• Target :

  Calcium Channel; Parasite; Potassium Channel

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology

• Purity :

  99.90

• Solubility :

  DMSO : 5 mg/mL (ultrasonic; warming)

• Smiles :

  COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC

• Molecular Formula :

  C38H42N2O6

• Molecular Weight :

  622.75

• Precautions :

  H300

• References & Citations :

  [1]Wang G, et al. Tetrandrine blocks a slow, large-conductance, Ca (2+) -activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Arch. 1992 Sep;421 (6) :558-65.|[2]Zhang Z, et al. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. J Exp Clin Cancer Res. 2018 Jan 15;37 (1) :7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [518-34-3]