Sp-TTPαS (tetrasodium)

• Description:

  Sp-TTPαS tetrasodium is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS tetrasodium competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM[1].

• UNSPSC:

  12352005

• Target:

  HIV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection; Inflammation/Immunology

• Smiles:

  O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO[P@@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(S[Na])=O

• Molecular Formula:

  C10H13N2Na4O13P3S

• Molecular Weight:

  586.16

• References & Citations:

  [1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported