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Phenoxodiol (Standard)

CAT: 0804-HY-13721R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13721R-01Size:1 mg
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Description
Phenoxodiol (Standard) is the analytical standard of Phenoxodiol. This product is intended for research and analytical applications. Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].
CAS Number
81267-65-4
UNSPSC
12352100
Target
Apoptosis; Caspase; Reference Standards; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1
Molecular Formula
C15H12O3
Molecular Weight
240.25
References & Citations
[1]Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22 (17) :2611-20.|[2]Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14 (1) :110.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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