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Phenoxodiol

CAT: 0804-HY-13721-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13721-01Size:5 mg
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Description
Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].
CAS Number
81267-65-4
Product Name Alternative
Idronoxil; Dehydroequol; Haginin E
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phenoxodiol.html
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1
Molecular Formula
C15H12O3
Molecular Weight
240.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22 (17) :2611-20.|[2]Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14 (1) :110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
BA2912-25Phenoxodiol
A21147-2Phenoxodiol 2mg
A21147-25Phenoxodiol 25mg
A21147-1Phenoxodiol 1mg
A21147-10Phenoxodiol 10mg
A21147-5Phenoxodiol 5mg
A21147-100Phenoxodiol 100mg
A21147-50Phenoxodiol 50mg
C14377-5mgPhenoxodiol (Haginin E)
A21147-10mM-DPhenoxodiol 10mM * 1mL in DMSO

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