1α-Hydroxyvitamin D5

CAT: 0804-HY-13692Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13692Size:1 Each
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease[1].
CAS Number
[187935-17-7]
Product Name Alternative
CARD-024
UNSPSC
12352211
Target
COX; FAK; Interleukin Related; Myosin
Related Pathways
Cytoskeleton; Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
Molecular Formula
C29H48O2
Molecular Weight
428.69
References & Citations
[1]Johnson LA, et al. CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts. Exp Mol Pathol. 2012 Aug;93 (1) :91-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
COX-2; IL-1

Popular Products