1α-Hydroxyvitamin D5

• Description :

  1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease[1].

• Product Name Alternative :

  CARD-024

• UNSPSC :

  12352211

• Target :

  COX; FAK; Interleukin Related; Myosin

• Related Pathways :

  Cytoskeleton; Immunology/Inflammation; Protein Tyrosine Kinase/RTK

• Field of Research :

  Inflammation/Immunology

• Smiles :

  C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C

• Molecular Formula :

  C29H48O2

• Molecular Weight :

  428.69

• References & Citations :

  [1]Johnson LA, et al. CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts. Exp Mol Pathol. 2012 Aug;93 (1) :91-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  COX-2; IL-1

• CAS Number :

  [187935-17-7]