Products for Research Use Only
RegisterLogin

PJ34 (hydrochloride) (Standard)

CAT: 0804-HY-13688RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13688RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PJ34 (hydrochloride) (Standard) is the analytical standard of PJ34 (hydrochloride) . This product is intended for research and analytical applications. PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
CAS Number
344458-15-7
UNSPSC
12352100
Target
PARP; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl
Molecular Formula
C17H18ClN3O2
Molecular Weight
331.80
References & Citations
[1]Iwashita A, et al. A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3- (4-phenyl-3,6-dihydro-1 (2H) -pyridinyl) propyl]-4 (3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly (ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149 (1) :23-30.|[3]Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7 (1) :2268.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

PJ-34 hydrochloride

PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It contains a PJ34(1+).

CAS Number344458-15-7
PubChem CID16760621
IUPAC Name2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride
Molecular FormulaC17H18ClN3O2
Molecular Weight331.8
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity438
SMILES
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
InChI
InChI=1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H
InChIKey
RURAZZMDMNRXMI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PJ-34 hydrochloride
CAS: 344458-15-7
CID: 16760621
Formula: C17H18ClN3O2
MW: 331.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass331.1087545
Monoisotopic Mass331.1087545
Topological Polar Surface Area61.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-13688AR-01PJ34 (Standard)
HY-13688-01PJ34 (hydrochloride)
HY-13688A-01PJ34
HY-N6029RDehydroevodiamine (hydrochloride) (Standard)
HY-N2368ARArecaidine (hydrochloride) (Standard)
HY-N0737R-01Harmine (hydrochloride) (Standard)
HY-N0300ARTetrahydropalmatine (hydrochloride) (Standard)
HY-B1404R-01Nylidrin (hydrochloride) (Standard)
HY-B1864ARKasugamycin (hydrochloride) (Standard)
HY-B0026RCeftiofur (hydrochloride) (Standard)

Alternative Products

CatalogName
A4159-5.1PJ34 hydrochloride
CS-ET-00040Trazodone hydrochloride impurity standard (591)
A3729-5PJ34
MBS577330PJ34 HCl
A15215-25PJ34 25mg
A15215-10PJ34 10mg

Popular Products