IPI-269609

CAT: 0804-HY-13654Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13654Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the "cancer stem cells" in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research[1].
CAS Number
[878204-96-7]
UNSPSC
12352005
Target
Hedgehog; Smo
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1CC[C@]2(C)[C@@]3([H])CC4=C(C)C[C@]([C@@H]5C)(CC[C@@]4([H])[C@]3([H])CCC2=C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6
Molecular Formula
C28H41NO2
Molecular Weight
423.63
References & Citations
[1]Feldmann G, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther. 2008 Sep;7 (9) :2725-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

Related Products

CatalogName
HY-111510-01IPI-3063
HY-124628-01IPI-9119
HY-P991254VPI-2690B

Alternative Products

CatalogName
MBS131565IPI549 (IPI-549; IPI 549)
MBS3602582-01IPI-549
M28096-01IPI-9119
M23579-01IPI-3063
452441-01IPI 549
MBS5781769IPI-493
sc-488318IPI 145
474116IPI-145

Popular Products