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Ascofuranone

CAT: 0804-HY-135562Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135562Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ascofuranone, a prenylphenol antibiotic, is a potent and selective trypanosome alternative oxidase (TAO) inhibitor. Ascofuranone has inhibitory activity against human dihydroorotate dehydrogenase (DHODH) . Ascofuranone has diverse physiological activities, including antibiotic, hypolipidemic, anti-inflammatory, and anti-cancer[1][2].
CAS Number
38462-04-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Purity
96
Smiles
C/C([C@@H]1CC(C(C)(O1)C)=O)=C\CC/C(C)=C/CC2=C(C(C=O)=C(C(Cl)=C2O)C)O
Molecular Formula
C23H29ClO5
Molecular Weight
420.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Fukai Y, et al. Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Oct;124 (2) :141-8. |[2]Araki Y, et al. Heterologous production of ascofuranone and ilicicolin A in Aspergillus sojae. J Gen Appl Microbiol. 2022 Jun 20;68 (1) :10-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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