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Ro4368554

CAT: 0804-HY-135456Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135456Size:1 Each
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Description
Ro4368554 is a brain-penetrant and selective 5-HT6 antagonist that reverses memory deficits induced by scopolamine and tryptophan depletion. Ro4368554 can be utilized in research related to memory deficits[1].
CAS Number
478082-99-4
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=S(C1=CNC2=C1C=CC=C2N3CCN(C)CC3)(C4=CC=CC=C4)=O
Molecular Formula
C19H21N3O2S
Molecular Weight
355.45
Precautions
P264-P270-P330-P501
References & Citations
[1]Lieben CK, et al. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology. 2005 Dec;30 (12) :2169-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2

Chemical Information

Ro4368554

the selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat

CAS Number478082-99-4
PubChem CID6918682
IUPAC Name3-(benzenesulfonyl)-7-(4-methylpiperazin-1-yl)-1H-indole
Molecular FormulaC19H21N3O2S
Molecular Weight355.5
XLogP2.8
Topological Polar Surface Area64.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity548
SMILES
CN1CCN(CC1)C2=CC=CC3=C2NC=C3S(=O)(=O)C4=CC=CC=C4
InChI
InChI=1S/C19H21N3O2S/c1-21-10-12-22(13-11-21)17-9-5-8-16-18(14-20-19(16)17)25(23,24)15-6-3-2-4-7-15/h2-9,14,20H,10-13H2,1H3
InChIKey
AOPYPEADLGTXRA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ro4368554
CAS: 478082-99-4
CID: 6918682
Formula: C19H21N3O2S
MW: 355.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.5
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass355.13544809
Monoisotopic Mass355.13544809
Topological Polar Surface Area64.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity548
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
464796-01Ro4368554

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