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DHNA

CAT: 0804-HY-134908-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134908-01Size:1 mg
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Description
DHNA (KIS20) is a PDH kinase 4 (PDK4) inhibitor with an IC50 of 18 μM. DHNA can be used for the study of heart failure[1].
CAS Number
117255-85-3
Product Name Alternative
1,4-Dihydroxy-6-naphthoic acid
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PDHK
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Concentration
10mM
Purity
99.65
Solubility
DMSO : 100 mg/mL
Smiles
O=C(C1=CC=C2C(O)=CC=C(O)C2=C1)O
Molecular Formula
C11H8O4
Molecular Weight
204.18
Precautions
H302, H312, H332
References & Citations
[1]Katsuhito Fujiu, et al. A therapeutic and prophylactic agent for heart failure containing a novel PDK4 inhibitor as an active ingredient. JP2015160831A.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,4-Dihydroxy-6-naphthoic acid

1,4-dihydroxy-6-naphthoic acid is a naphthalenediol that is naphthalene-1,4-diol bering a carboxy substituent at position 6. It is a member of naphthalenediols, a monocarboxylic acid and a naphthohydroquinone. It is a conjugate acid of a 1,4-dihydroxy-6-naphthoate.

CAS Number117255-85-3
PubChem CID14278030
IUPAC Name5,8-dihydroxynaphthalene-2-carboxylic acid
Molecular FormulaC11H8O4
Molecular Weight204.18
XLogP2
Topological Polar Surface Area77.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity253
SMILES
C1=CC2=C(C=CC(=C2C=C1C(=O)O)O)O
InChI
InChI=1S/C11H8O4/c12-9-3-4-10(13)8-5-6(11(14)15)1-2-7(8)9/h1-5,12-13H,(H,14,15)
InChIKey
HVZYIHBMRFYBRI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,4-Dihydroxy-6-naphthoic acid
CAS: 117255-85-3
CID: 14278030
Formula: C11H8O4
MW: 204.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight204.18
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass204.04225873
Monoisotopic Mass204.04225873
Topological Polar Surface Area77.8 Ų
Heavy Atom Count15
Formal Charge0
Complexity253
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T211287-01DHNA

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