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Methyltetrazine-PEG4-SS-NHS ester

CAT: 0804-HY-133466-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133466-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
95.0
Solubility
10 mM in DMSO
Smiles
CC1=NN=C(C2=CC=C(CNC(CCOCCOCCOCCOCCNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)=O)C=C2)N=N1
Molecular Formula
C31H43N7O10S2
Molecular Weight
737.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker

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