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(R) -Norfluoxetine

CAT: 0804-HY-133171Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133171Size:2.5 mg
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Description
(R) -Norfluoxetine is the (R) -enantiomer of Norfluoxetine. (R) -Norfluoxetine is a potent serotonin re-uptake inhibitor, with a Ki of 13 nM. (R) -Norfluoxetine can be used for the research of depression[1].
CAS Number
130194-43-3
UNSPSC
12352005
Hazard Statement
H319
Target
Serotonin Transporter
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC(F)(F)C1=CC=C(O[C@H](CCN)C2=CC=CC=C2)C=C1
Molecular Formula
C16H16F3NO
Molecular Weight
295.30
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Cashman JR, et al. Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17 (1) :337-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

(R)-Norfluoxetine
CAS Number130194-43-3
PubChem CID9797657
IUPAC Name(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
Molecular FormulaC16H16F3NO
Molecular Weight295.30
XLogP3.5
Topological Polar Surface Area35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count21
Formal Charge0
Complexity294
SMILES
C1=CC=C(C=C1)[C@@H](CCN)OC2=CC=C(C=C2)C(F)(F)F
InChI
InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2/t15-/m1/s1
InChIKey
WIQRCHMSJFFONW-OAHLLOKOSA-N
Chemical Structure
2D Structure
2D structure of (R)-Norfluoxetine
CAS: 130194-43-3
CID: 9797657
Formula: C16H16F3NO
MW: 295.30
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight295.30
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass295.11839862
Monoisotopic Mass295.11839862
Topological Polar Surface Area35.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity294
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes