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Hydrodolasetron

CAT: 0804-HY-133086-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133086-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydrodolasetron is a metabolite of Dolasetron. Hydrodolasetron is more potent than Dolasetron in inhibiting nAChR. Hydrodolasetron is a 5-HT (3A) R blocker with an IC50 of 0.29 nM. Hydrodolasetron has antiemetic activity[1].
CAS Number
127951-99-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; nAChR
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C1=CNC2=C1C=CC=C2)OC3CC4N5CC(O)C(C4)CC5C3
Molecular Formula
C19H22N2O3
Molecular Weight
326.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Paul M, et al. Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesth Analg. 2005 Sep;101 (3) :715-721.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Chemical Information

Mdl-74156
CAS Number127951-99-9
PubChem CID159502
IUPAC Name(10-hydroxy-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate
Molecular FormulaC19H22N2O3
Molecular Weight326.4
XLogP3.2
Topological Polar Surface Area65.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity497
SMILES
C1C2CC3CC(CC1N3CC2O)OC(=O)C4=CNC5=CC=CC=C54
InChI
InChI=1S/C19H22N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,18,20,22H,5-8,10H2
InChIKey
MLWGAEVSWJXOQJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mdl-74156
CAS: 127951-99-9
CID: 159502
Formula: C19H22N2O3
MW: 326.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight326.4
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass326.16304257
Monoisotopic Mass326.16304257
Topological Polar Surface Area65.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
RM-H251900-01Hydrodolasetron
RM-H251901-01S- (-) -Hydrodolasetron
AR-D02113-01Hydrodolasetron-d4

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