Tofersen-d27

• Description :

  Tofersen-d27 (BIIB067-d27) is the deuterium labeled Tofersen (HY-132580) . Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) [1].

• Product Name Alternative :

  BIIB067-d27; ISIS-SOD1Rx-d27; ISIS 333611-d27

• UNSPSC :

  12352208

• Target :

  DNA/RNA Synthesis; Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  [Tofersen-d27]

• Molecular Formula :

  C230H290D27N72O123P19S15

• Molecular Weight :

  7155.18

• References & Citations :

  [1]Miller T, et, al. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med. 2020 Jul 9;383 (2) :109-119. |[2]McCampbell A, et, al. Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. J Clin Invest. 2018 Aug 1;128 (8) :3558-3567.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported