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Tofersen (sodium)

CAT: 0804-HY-132580A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132580A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS) [1].
CAS Number
1898254-60-8
Product Name Alternative
BIIB067 (sodium) ; ISIS-SOD1Rx (sodium) ; ISIS 333611 (sodium)
UNSPSC
12352208
Target
DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tofersen-sodium.html
Purity
97.19
Solubility
10 mM in H2O
Smiles
[Tofersen(sodium)]
Molecular Formula
C230H298N72Na19O123P19S15
Molecular Weight
7128 (free acid)
References & Citations
[1]Miller T, et, al. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med. 2020 Jul 9;383 (2) :109-119. |[2]McCampbell A, et, al. Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. J Clin Invest. 2018 Aug 1;128 (8) :3558-3567.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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