7-Hydroxymethotrexate (sodium)

• Description:

  7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

• UNSPSC:

  12352211

• Target:

  Drug Metabolite

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C(C=C1)=CC=C1N(C)CC2=NC(C(N)=NC(N)=N3)=C3N=C2O[Na])=O

• Molecular Formula:

  C20H19N8Na3O6

• Molecular Weight:

  536.38

• References & Citations:

  [1]L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23 (3) :156-60.|[2]Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43 (5) :1789-95.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported