W-7

W-7 is a selective calmodulin antagonist. W-7 inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 induces apoptosis and has antitumor and vascular relaxing activity. W-7 is a blocker of Kv4.3 and can be used for research of arrhythmias[1][2][3][4][5][6].

65595-90-6

12352005

Apoptosis; Calmodulin; Myosin; Phosphodiesterase (PDE) ; Potassium Channel

Apoptosis; Cytoskeleton; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Cardiovascular Disease

90.000000

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCCCN)=O

C16H21ClN2O2S

340.87

[1]Qu YJ, et al. W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition. Am J Physiol Heart Circ Physiol. 2007 May;292 (5) :H2364-77.|[2]Gbadebo TD, et al. Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes. Circulation. 2002 Feb 12;105 (6) :770-4.|[3]H Hidaka, et al. N- (6-aminohexyl) -5-chloro-1-naphthalenesulfonamide, a Calmodulin Antagonist, Inhibits Cell Proliferation. Proc Natl Acad Sci U S A. 1981 Jul;78 (7) :4354-7.|[4]M Asano. Divergent Pharmacological Effects of Three Calmodulin Antagonists, N- (6-aminohexyl) -5-chloro-1-naphthalenesulfonamide (W-7), Chlorpromazine and Calmidazolium, on Isometric Tension Development and Myosin Light Chain Phosphorylation in Intact Bovine Tracheal Smooth Muscle. J Pharmacol Exp Ther. 1989 Nov;251 (2) :764-73.|[5]H Itoh, et al. Direct Interaction of Calmodulin Antagonists With Ca2+/calmodulin-dependent Cyclic Nucleotide Phosphodiesterase. J Biochem. 1984 Dec;96 (6) :1721-6.H Itoh, et al. Direct Interaction of Calmodulin Antagonists With Ca2+/calmodulin-dependent Cyclic Nucleotide Phosphodiesterase. J Biochem. 1984 Dec;96 (6) :1721-6.|[6]Shigeyuki Yokokura, et al. Calmodulin Antagonists Induce Cell Cycle Arrest and Apoptosis in Vitro and Inhibit Tumor Growth in Vivo in Human Multiple Myeloma. BMC Cancer. 2014 Nov 26;14:882.

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