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IAXO-101 (iodide)

CAT: 0804-HY-129684Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129684Size:1 Each
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Description
IAXO-101 iodide is a TLR4/CD14 blocker. IAXO-101 iodide can inhibit the innate immune pathway of CD14. IAXO-101 iodide is capable of improving the recording performance of intracortical microelectrodes in mice. IAXO-101 iodide can also partially alleviate fetal growth restriction, placental vascular damage, and reduce the level of the inflammatory factor TNF-α in pregnant mice infected with malaria. IAXO-101 iodide can be used in the research of gestational malaria and inflammatory diseases[1][2].
CAS Number
1202388-64-4
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@@H](C[N+](C)(C2CCCC2)C)O[C@@H]1OC)O)OCCCCCCCCCCCCCC.[I-]
Molecular Formula
C42H84INO5
Molecular Weight
810.02
References & Citations
[1]Hermann JK, et al. Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng. 2018 Apr;15 (2) :025002.|[2]Barboza R, et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. Sci Rep. 2017 Aug 17;7 (1) :8623.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR4

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