Echothiopate iodide

• Description:

  Echothiopate iodide is a potent hBChE (human butyrylcholinesterase) inhibitor. Echothiopate iodide is a long-acting anticholinesterase agent. Echothiopate iodide can be used for glaucoma research[1][2].

• Product Name Alternative:

  Echothiophate iodide

• UNSPSC:

  12352211

• Hazard Statement:

  H300-H311+H331-H400

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/echothiopate-iodide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(SCC[N+](C)(C)C)(OCC)OCC.[I-]

• Molecular Formula:

  C9H23INO3PS

• Molecular Weight:

  383.23

• Precautions:

  P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501

• References & Citations:

  [1]Nachon F, et al. Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging. Biochemistry. 2005 Feb 1;44 (4) :1154-62.|[2]HUMPHREYS JA, et al. Systemic effects produced by echothiophate iodide in treatment of glaucoma. Arch Ophthalmol. 1963 Jun;69:737-43.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  BChE

• CAS Number:

  513-10-0