RYL-634

• Description :

  RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases[1].

• CAS Number :

  [2187352-99-2]

• UNSPSC :

  12352005

• Target :

  Dengue Virus; HCV; Influenza Virus

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C1C(C)=C(C2=CC(F)=C(OC3=CC=C(N(CC)CC)C=C3)C=C2)NC4=CC=CC(F)=C41

• Molecular Formula :

  C26H24F2N2O2

• Molecular Weight :

  434.48

• References & Citations :

  [1]Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors. J Med Chem. 2019 Apr 25;62 (8) :4056-4073.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported