RYL-552

• Description :

  RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor[1].

• UNSPSC :

  12352005

• Target :

  Mitochondrial Metabolism; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ryl-552.html

• Concentration :

  10mM

• Purity :

  98.63

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C)=C(NC2=C1C(F)=CC=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F

• Molecular Formula :

  C24H17F4NO2

• Molecular Weight :

  427.39

• References & Citations :

  [1]Kristin D Lane, et al. Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors. Proc Natl Acad Sci U S A. 2018 Jun 12;115 (24) :6285-6290.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium

• CAS Number :

  [1801444-56-3]