BPTES (Standard)

CAT: 0804-HY-12683R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12683R-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPTES (Standard) is the analytical standard of BPTES. This product is intended for research and analytical applications. BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM.
CAS Number
[314045-39-1]
UNSPSC
12352100
Target
Glutaminase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(NC1=NN=C(CCSCCC2=NN=C(NC(CC3=CC=CC=C3)=O)S2)S1)CC4=CC=CC=C4
Molecular Formula
C24H24N6O2S3
Molecular Weight
524.68
References & Citations
[1]Elgogary A, et al. Combination therapy with BPTES nanoparticles and targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113 (36) :E5328-36.|[2]Meghan J. Seltzer, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15; 70 (22) : 8981-8987.|[3]Lee JS, et al. Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC. Biochem Biophys Res Commun. 2016 Aug 26;477 (3) :374-82|[4]Lee JS, et al. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death Dis. 2016 Dec 8;7 (12) :e2511.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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