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Molidustat (Standard)

CAT: 0804-HY-12654R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12654R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Molidustat (Standard) is the analytical standard of Molidustat. This product is intended for research and analytical applications. Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia[1][2].
CAS Number
1154028-82-6
UNSPSC
12352100
Target
HIF/HIF Prolyl-Hydroxylase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C1C(N2N=NC=C2)=CNN1C3=NC=NC(N4CCOCC4)=C3
Molecular Formula
C13H14N8O2
Molecular Weight
314.30
References & Citations
[1]Flamme I, et al. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One. 2014 Nov 13;9 (11) :e111838.|[2]Yamamoto H, et al. Molidustat for Renal Anemia in Nondialysis Patients Previously Treated with Erythropoiesis-Stimulating Agents: A Randomized, Open-Label, Phase 3 Study. Am J Nephrol. 2021;52 (10-11) :884-893.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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