ASP 8477

• Description :

  ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values ​​of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research[1].

• CAS Number :

  [906737-25-5]

• UNSPSC :

  12352005

• Target :

  FAAH

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(N1CCC(C(NC2=CC=CC=C2)=O)CC1)OC3=CC=CN=C3

• Molecular Formula :

  C18H19N3O3

• Molecular Weight :

  325.36

• References & Citations :

  [1]Watabiki T, et al. In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor[J]. European Journal of Pharmacology, 2017, 815: 42-48.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  FAAH-1; FAAH-2