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HL001

CAT: 0804-HY-124072-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124072-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1) . HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis[1][2].
CAS Number
1186371-31-2
UNSPSC
12352005
Target
Apoptosis; Cyclophilin; LPL Receptor; MDM-2/p53; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Purity
98.90
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC(C(C(O)=CC=C1)=C1O)=O)NC2C3=CC=CC=C3C4=CC=CC=C24
Molecular Formula
C21H16N2O4
Molecular Weight
360.36
References & Citations
[1]Lu W, et al. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017 Aug 17;36 (33) :4719-4731.|[2]Yuki Y, et al. Preclinical evaluation of HL001, a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, for idiopathic pulmonary fibrosis utilizing physiologically relevant stem cell-derived lung organoids. European Respiratory Journal 2023 62 (suppl 67) : OA898.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A; LPAR1

Alternative Products

CatalogName
M10634HL001

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