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SB772077B

CAT: 0804-HY-123958Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123958Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research[1][2].
CAS Number
785774-34-7
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Collagen; ROCK; β-catenin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cardiovascular Disease; Inflammation/Immunology; Neurological Disease
Smiles
NC1=NON=C1C(N2CC)=NC3=C2C(C(N4C[C@@H](N)CC4)=O)=CN=C3
Molecular Formula
C15H18N8O2
Molecular Weight
342.36
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Ashwinbalaji S, et al. SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes. Sci Rep. 2018 Oct 19;8 (1) :15472. |[2]Dhaliwal J S, et al. Analysis of pulmonary vasodilator responses to SB-772077-B [4- (7- ((3-amino-1-pyrrolidinyl) carbonyl) -1-ethyl-1H-imidazo (4, 5-c) pyridin-2-yl) -1, 2, 5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor[J]. The Journal of pharmacology and experimental therapeutics, 2009, 330 (1) : 334-341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Collagen I

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CatalogName
GTR19273703-01SB772077B

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