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R116031

CAT: 0804-HY-123497Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123497Size:1 Each
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Description
R116031 is a selective Neurokinin-1 (NK-1) receptor antagonist with a Ki of 0.45 nM for human NK-1 receptor. R116031 inhibits Substance P -induced peripheral effects (skin reactions and plasma extravasation in guinea pigs) and a central effect (thumping in gerbils).R116031 labeled with 3H significantly accumulate in the striatum, olfactory tubercule, olfactory bulb and locus coeruleus in gerbils models. R116031 can be used as a positron emission tomography (PET) ligand for PET imaging[1].
CAS Number
336884-84-5
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N2[C@@H](C[C@@H](N3CCN(CC3)CC(NC4=C(C=CC=C4C)C)=O)CC2)CC5=CC=CC=C5
Molecular Formula
C35H38F6N4O2
Molecular Weight
660.69
References & Citations
[1]Van der Mey M, et al. Synthesis and biodistribution of [ (11) C]R116301, a promising PET ligand for central NK (1) receptors. Bioorg Med Chem. 2005 Mar 1;13 (5) :1579-86.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T34241-01R116031

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