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Ro 61-8048 (Standard)

CAT: 0804-HY-12347R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12347R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 61-8048 (Standard) is the analytical standard of Ro 61-8048. This product is intended for research and analytical applications. Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1].
CAS Number
199666-03-0
UNSPSC
12352100
Target
KMO; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease
Smiles
O=S(C1=CC=C(OC)C(OC)=C1)(NC2=NC(C3=CC=CC([N+]([O-])=O)=C3)=CS2)=O
Molecular Formula
C17H15N3O6S2
Molecular Weight
421.45
References & Citations
[1]S Röver, et al. Synthesis and biochemical evaluation of N- (4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40 (26) :4378-85.|[2]Melanie Hamann, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586 (1-3) :156-9.|[3]AlbertoChiarugi, et al. Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl) -alanine (mNBA) and 3,4-dimethoxy-[-N-4- (-3-nitrophenyl) thiazol-2yl]-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. Neuropharmacology. Volume 38, Issue 8, August 1999, Pages 1225-1233.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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