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Ro 20-1724 (Standard)

CAT: 0804-HY-100927R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100927R-01Size:5 mg
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Description
Ro 20-1724 (Standard) is the analytical standard of Ro 20-1724. This product is intended for research and analytical applications. Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].
CAS Number
29925-17-5
Product Name Alternative
Ro 20-174 (Standard)
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease
Smiles
O=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1
Molecular Formula
C15H22N2O3
Molecular Weight
278.35
References & Citations
[1]Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4- (3-butoxy-4-methoxybenzyl) imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38 (24) :4848-4854. |[2]Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101 (2) :239-245.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

4-((3-Butoxy-4-methoxyphenyl)methyl)-2-imidazolidinone

4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.

CAS Number29925-17-5
PubChem CID5087
IUPAC Name4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
Molecular FormulaC15H22N2O3
Molecular Weight278.35
XLogP2.4
Topological Polar Surface Area59.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Heavy Atom Count20
Formal Charge0
Complexity311
SMILES
CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC
InChI
InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChIKey
PDMUULPVBYQBBK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-((3-Butoxy-4-methoxyphenyl)methyl)-2-imidazolidinone
CAS: 29925-17-5
CID: 5087
Formula: C15H22N2O3
MW: 278.35
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight278.35
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Exact Mass278.16304257
Monoisotopic Mass278.16304257
Topological Polar Surface Area59.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity311
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes