RL71-d6

CAT: 0804-HY-121605SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-121605SSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RL71-d6 is a deuterium labeled RL71 (HY-121605) . RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks[1].
UNSPSC
12352005
Target
Apoptosis; Isotope-Labeled Compounds
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC([2H])([2H])[2H])C)=C/C3=CC(OC)=C(C(OC)=C3)OC([2H])([2H])[2H]
Molecular Formula
C26H25D6NO7
Molecular Weight
475.56
References & Citations
[1]Yadav B, et al. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. Int J Oncol. 2012 Sep;41 (3) :1119-27.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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