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S 16317

CAT: 0804-HY-120790Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120790Size:1 Each
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Description
S 16317 is an orally active dihydropyridine derivative with low calcium channel affinity (Ki: 0.55 μM) . S 16317 inhibits P-gp mediated efflux of ADR. S 16317 overcomes multidrug resistance in tumor[1].
CAS Number
151489-04-2
UNSPSC
12352005
Target
Calcium Channel; P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cancer
Smiles
O=C(OC)C1=C(NC(COCCOCCNCC2=CC=NC=C2)=C(C1C3=C(Cl)C(Cl)=CC=C3)C(OCC)=O)C
Molecular Formula
C28H33Cl2N3O6
Molecular Weight
578.48
References & Citations
[1]Leonce S, et al. Multidrug-resistance circumvention and inhibition of [h-3] azidopine photolabeling of p-glycoprotein by new dihydropyridine derivatives displaying a low-affinity for calcium channels. Int J Oncol. 1994 Jun;4 (6) :1243-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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