WAY-255348

• CAS Number :

  872141-23-6

• Target :

  Others|||Progesterone Receptor

• Related Pathways :

  Others

• Bioactivity :

  WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.

• Smiles :

  CC1(C)C=2C(=C(F)C=C(C2)C=3N(C)C(C#N)=CC3)NC1=O

• Molecular Formula :

  C16H14FN3O

• Molecular Weight :

  283.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C