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WAY-255348

CAT: 0931-T68473-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68473-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
872141-23-6
Target
Others|||Progesterone Receptor
Related Pathways
Others
Bioactivity
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.
Smiles
CC1(C)C=2C(=C(F)C=C(C2)C=3N(C)C(C#N)=CC3)NC1=O
Molecular Formula
C16H14FN3O
Molecular Weight
283.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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