AB1

• Description :

  AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM) . AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; LPL Receptor

• Related Pathways :

  Apoptosis; GPCR/G Protein

• Field of Research :

  Cancer

• Smiles :

  C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21

• Molecular Formula :

  C19H21Cl2N7O

• Molecular Weight :

  434.32

• References & Citations :

  [1]Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354 (3) :261-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  S1PR2

• CAS Number :

  [1463912-49-3]