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AB1

CAT: 0804-HY-120409Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120409Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM) . AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors[1].
CAS Number
1463912-49-3
UNSPSC
12352005
Target
Apoptosis; LPL Receptor
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Cancer
Smiles
C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21
Molecular Formula
C19H21Cl2N7O
Molecular Weight
434.32
References & Citations
[1]Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354 (3) :261-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR2

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