FR-182980

• Description :

  FR-182980 is an orally active ACAT1 inhibitor (IC50: 30 nM) . FR-182980 has hypocholesterolemic activity and can be used for research of atherosclerosis[1].

• CAS Number :

  [179054-51-4]

• UNSPSC :

  12352005

• Target :

  Acyltransferase

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  O=C(NC1=C(SC)C=C(C)N=C1SC)N(C2CCCCCC2)CC3=CC=C(OC4=CC=C(F)C=C4)C=C3

• Molecular Formula :

  C29H34FN3O2S2

• Molecular Weight :

  539.73

• References & Citations :

  [1]Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) . Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas. Bioorg Med Chem. 1998 Jan;6 (1) :15-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported